Arun K Aggarwal, Harmeet Singh, Harmeet Singh, Anshika Rana, Anshika Rana


Background: The main aim of our research was to study the role of an isoprenoid compound's (gamma and delta Tocotrienol) in the radiation
induced conditions like oesophageal stricture (dysphagia), trismus with neck stiffness, and cervical dystonia after radical radiotherapy treatment in
cancer patients.
Method: In this study, histo-pathologically proved patients of oesophageal, head/neck and cervical cancer were selected after radical radiotherapy
treatment which presented at Department of Radiation, Aadhar Hospital, Hisar, India. The patients who developed trismus with neck stiffness,
cervical dystonia and oesophageal stricture after radical radiotherapy were divided into two group I & II. Group I patients were treated with gamma
and delta tocotrienol (50%) capsules along with conventional treatment and group II patients were taken as reference group and was given
conventional treatment.
Results: The selected patients were treated for six months with Tocotrienol capsules and evaluated for radiotherapy complications like dysphagia,
trismus with neck stiffness, cervical dystonia, radiation induced fibrosis. The oesophageal stricture, trismus with neck stiffness, cervical dystonia
conditions were improved up-to 80-90%. Other quality of life measures like emotional liability, depression, able to work normally at their
workplaces/ general well-being of the patient were also analysed and were seen to be improved.
Conclusion: Gamma and delta Tocotrienol given after radical radiation treatment for six months have significant and subjective improvement of
symptoms. Moreover, these patients quality of life like social life was also better, they feel good. Furthermore, a multi-centric randomized study
will be more beneficial to evaluate the role of tocotrienols in radiotherapy complications

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Liao, ZX, Komaki, RR, Thames, HD Influence of technologic advances on outcomes in patients with unresectable, locally advanced non-small cell lung cancer receiving concomitant chemoradiotherapy. Int J Radiat Oncol Biol Phys 2010;76:775–781.

Herskovic, A, Martz, LK, Al-Sarraf, M Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus. N Engl J Med 1992; 326: 1593–1598.

Nguyen, NP, Moltz, CC, Frank, C Dysphagia following chemoradiation for locally advanced head and neck cancer. Ann Oncol 2004; 15: 383–388.

Smith, RV, Kotz, T, Beitler, JJ Long-term swallowing problems after organ preservation therapy with concomitant radiation therapy and intravenous hydroxyurea: initial results. Arch Otolaryngol Head Neck Surg 2000; 126: 384–389.

Jung-Hoon P, Kun Yung K, Ho-Young S, Young CC, Pyeong HK, Jiaywei T, Min Tae K, Eun Jung J, Hwoon-Yong J, Sung-Bae K, Jong Hoon K. Radiation-induced esophageal strictures treated with fluoroscopic balloon dilation: clinical outcomes and factors influencing recurrence in 62 patients, Acta Radiologica 59(3), 313–321, 2018

Kamleshwar S, Upadhyay SR, Habib AA, Rajeev KS, Management of trismus following radiation therapy by cost-effective approach, BMJ Case Rep. 2012; 2012.

Swaroop VS, Desai DC, Mohandas KM, Dhir V, Dave UR, Gulla RI, Dinshaw KA, Deshpande RK, Desai PB, Dilation of esophageal strictures induced by radiation therapy for cancer of the esophagus, Gastrointest Endosc. 1994 May-Jun; 40(3): 311-315.

Alexander A, Massoud AA, Eleftheria A, Signe F, Henrik H, Panayiotis M, Bengt KL, Goran L, Esophageal Stricture After Radiotherapy In Patients With Head And Neck Cancer: Experience Of A Single Institution Over 2 Treatment Periods, Esophageal Stricture after Radiotherapy, Head & Neck, 2010, 452-461.

Katarzyna H, Piotr M, Opportunities for rehabilitation of patients with radiation fibrosis syndrome, Rep Pract Oncol Radiother. 2014; 19(1): 1–6.

Kumar D, Aggarwal AK, Shukla DK, Gleetus Thimothy and Shaili Rani, To study and evaluation of role of gamma and delta tocotrienol in radiation induced fibrosis, The Pharma Innovation Journal 2017; 6(4): 91-94.


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