PRIMARY COLD AGGLUTININ DISEASE IN ADOLESCENT AGE – A RARE PRESENTATION

Abstract

Cold agglutinin disease is a rare form of autoimmune hemolytic anemia caused by cold reacting autoantibodies directing against the RBC membrane antigens . Majority of cases of Cold agglutinin disease are secondary to infections , autoimmune diseases and Lymphoproliferative disorders . Primary cold agglutinin disease is extremely rare with estimated Incidence of 1 per million and prevalence of 16 per million with the mean age of presentation being 67 years . A high index of suspicion and meticulous work up is required for diagnosis of primary cold agglutinin disease . Hereby , we aim to discuss a case of Primary cold agglutinin disease presented at adolescent age and it’s management .