Dr Reema Rana, Dr Rakesh Shedge


Histologically, cholestasis is presence of visible bile in tissue sections. Normally liver biopsy does not show presence of bile, if present it is always pathological. Cholestasis can be either intrahepatic or extrahepatic. Extrahepatic causes are mostly diagnosed with radiological investigations like USG, CT and MRI. Liver biopsy is indicated in intrahepatic causes of cholestasis. Intrahepatic cholestasis on liver biopsy shows four patterns namely acute cholestasis with large duct obstruction, bland cholestasis, intrahepatic bile duct loss or ductopenia and cholestasis associated with hepatitis. These four patterns are derived based on the histological changes seen in liver parenchyma and portal tract.


Cholestasis, Intrahepatic, Patterns

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