COMPARISION STUDY OF LIPID PROFILES IN BREAST CANCER PATIENTS AND HEALTHY CONTROL GROUP

Dr. Renu Meena, Dr. Shakuntala Saini

Abstract


Carcinoma of the breast is the second commonest malignancy affecting half a million women worldwide
each year. Epidemiological studies have revealed that 1 in 50 women in India can develop breast cancer
in their lifetime. A number of epidemiological studies have shown the increased risk of death from cancer with
hypocholesterolaemia, although several studies proposed the low levels of cholesterol is a predisposing factor for
carcinogenesis. So the present study was planned to investigate the alteration in the lipid proles of patients with carcinoma of
breast in comparison with age matched control women.
Aim: Estimate and compare Serum Lipid Prole for both in Breast cancer patients and normal individuals.
Materials & Methods: Overnight Fasting blood samples of 156 Clinically diagnosed female cases of breast cancer from
OPD/IPD of Surgery and Oncology department And same number of normal individuals or control group has been taken from
the OPD/IPD of Medicine Department and Emergency Department, S.M.S. Medical College and Hospital, Jaipur.Esmination of
Serum Lipid Proles Such as Total Cholesterol,HDL-Cholesterol, etc. were determine by enzymatic method in fully automated
chemistry analyzer.
Observation & Result:Mean±SD (mg/dl) for Serum TG level, in case of Breast Cancer Patients & Control Group were
202.74±53.45 and 178.77±99.36 respectively and p value was 0.008. Similarly, for Serum Cholesterol were 205.62±46.09 and
158.73±41.59 for Breast Cancer and Control group respectively.Also, p value of S.Cholesterol was 0.000. Mean and SD of
S.HDL-Cholesterol level for both the groups were 39.20±5.30 and 40.46±8.96 respectively, p value was non signicant. As far
as S.LDL level was concert for Breast Cancer patients was 125.87±46.97 and for the control group was 81.54±29.21 and p value
was 0.000. Level of S. VLDL were 40.55±10.69 and 35.70±19.49 for test group and control group respectively and p value was
0.008.
Summary & Conclusion:Serum Cholesterol,Serum LDL was signicantly lower in breast cancer patients whereas Serum
TG,VLDL was signicantly higher in breast cancer patients. Carcinoma breast is commonest cancer in urban and rural
females. Many women donot present themselves for check-up at hospitals or Medical because of varied reasons like illiteracy,
monetary reasons and lack of knowledge. .Lots of efforts are needed both from the health systems as well as from local
population for early diagnosis of cancer breast


Keywords


Breast Cancer, HDL,VLDL,LDL,Cholesterol

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References


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