Md. Shahimur Parvez, Mohammad Arifur Rahman, Md. Moniruzzaman, Arin Islam Lita, Tamal Peter Ghosh, Abdul Wadud Chowdhury


Background: Dyslipidaemia contributes to substantial increased risk of premature extensive and accelerated atherosclerosis leading to CAD, PVD and MI etc. Patients derive most benefit from treatment with lipid-lowering agents.

Objective: To evaluate the pattern of dyslipidaemia in patients with angiogram documented significant coronary artery disease (lesion ≥70 % stenosis).

Methods: This cross sectional analytical study was carried out in the Department of Cardiology, Dhaka Medical College Hospital, Dhaka; University Cardiac Centre (UCC), Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka and Department of Cardiology, Ibrahim Cardiac Hospital & Research Institute, Shahbag, Dhaka (March 2011 to August 2011). A total number of 50 patients with angiogram documented coronary artery disease were included in this study. Stenosis ≥ 70% in any of the three major epicardial vessels was considered significant CAD. Total Cholesterol ≥200 mg/dl or LDLc ≥130 mg/dl or HDLc ≤40 mg/dl or Triglyceride ≥200 mg/dl were considered as dyslipidaemia. Considering the inclusion & exclusion criteria the study population were divided into two groups. Group-I: Patients with dyslipidaemia (n=43) and Group-II: Patients without dyslipidaemia (n=07).

Results: Almost one third (32.0%) of the patients were in 6th decade and male to female ratio was 5.3:1. Eighty percent of the patients had typical chest pain and 16.0% had shortness of breath. Regarding the traditional risk factors, dyslipidaemia (86.0%) was more common followed by hypertension (66.0%), diabetes (42.0%), smoking (40.0%) and family history of IHD (28.0%). Mean BMI of the Group-I was 25.46±3.69 and Group-II was 24.65 ± 4.21. Left main involvement was found in 4.0% and most of the patients (60.0%) had significant proximal lesion involvement that were 40.0% in LAD, 18.0% in LCX and 22.0% in RCA. The mean difference of fasting lipid profile was not statistically significant between smoker and non-smoker patients, hypertensive and normotensive, diabetic and non-diabetic patients with angiogram documented coronary artery disease (P>0.05).

Conclusion: Most of the patients with coronary artery disease had low HDL (84.0%) irrespective of taking lipid lowering medication.


Dyslipidaemia, Coronary Angiography, Coronary Artery Disease

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