ATTENUATION OF HEMODYNAMIC RESPONSE TO ENDOTRACHEAL INTUBATION USING ORAL IVABRADINE - A PROSPECTIVE RANDOMISED CONTROLLED DOUBLE BLIND STUDY

Dr.Syed Rubiya Sultana, Dr.Renu Devaprasath, Dr. S. NishalPerumal, Dr Renjith I

Abstract


BACKGROUND:Rapid and dramatic hemodynamic changes which adversely affect the patient may occur during laryngoscopy and intubation. The present study evaluates the effect of oral ivabradine on the hemodynamics during laryngoscopy and endotracheal intubation in patients undergoing surgical procedures under general anesthesia with ETT.

STUDY DESIGN: A prospective, randomized, controlled, double-blind study.

MATERIAL AND METHODS : 90 ASA I and II patients who underwent elective surgeries under general anaesthesia at Dr Jeyasekharan Hospital and Nursing Home, were randomly divided into two groups of 45 each. Group A received Tab Ivabradine 5 mg and group B  received Tab B complex.The hemodynamic parameters namely HR,SBP,DBP and MAP were monitored prior to the study drug as baseline and at the following time intervals ;after induction, after intubation, ,after 1,3,5,8 and 10 minutes after intubation.

RESULTS: HR was significantly lower in the ivabradine group compared to control group at all time interval after study drug. SBP,DBP&MAP were significantly lower in the Ivabradine group compared to control group after induction,  after intubation, and  1,3,5,8 and 10 minutes after intubation.

CONCLUSIONS: Ivabradine   given before intubation prevents significant rise in HR and SBP, DBP, MAP compared to placebo in patients during  laryngoscopy  and endotracheal intubation.

Keywords


Laryngoscopy, intubation, anaesthesia, Hypertension

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References


C. G.R. Singh D, Kabra Av. Attenuation Of Hemodynamic Response To Laryngoscopy And Endotracheal Intubation Using Intra-Oral Ivabradine: A Clinical Study. J Evol Med Dent Sci. 2014 Aug 27;3(39):9944–55

Prevention of Haemodynamic Changes during Laryngoscopy and Endotracheal Intubation- A Clinical Study of Oral Ivabradine Rajesh Kunwer1 , Mamta Joshi2 , Saurabh Pathak ISSN (Online): 2393-915X; (Print): 2454-7379 | ICV: 50.43 | Volume 3 | Issue 7 | July 2016

K.D. Tripathy M.D. Essentials of medical pharmacology 7th edition. Chapter 39;559. Chapter 29 ; page361- 366.

Ibrahim A, Atallah R. Ivabradine versus propranolol given orally in microlaryngoscopic surgeries in attenuating stress response: A comparative prospective double blind randomized study. Egyptian Journal of Anaesthesia. 2016;32(4):503-511.

A. J. Shribman, g. Smith and k. J. Achola Cardiovascular and catecholamine responses To laryngoscopy with and without Tracheal intubation A. J. Shribman, g. Smith and k. J. Achola Br. J. Anaesth. (1987), 59, 295-299.


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