Dr. Mayank Shukla, Dr. Syed Javed


Background- In this study, we determined serum prolactin level in patients with acute stroke and assessed its relationship with disease severity. Method- This is an observational, case control study on patients diagnosed with acute ischemic stroke in Geetanjali Medical College and Hospital, Udaipur.50 cases and 50 controls were included in the study.Serum prolactin level along with other blood routine tests were done.Results- The mean age group in cases was 60.04±2.04 years and in control was 48.76±2.399 years. Male preponderance was seen in both cases and control.Mean serum prolactin level in cases was 39.678±5.488 and in control was 9.998±0.942 ng/ml, this difference was statistically significant at p value of <0.05. The correlation between serum uric acid levels and severity of stroke on basis of GCS score was not significant. Conclusion- This study concludes that Serum prolactin level can be used as pathological biomarker in patients of acute ischemic stroke but of severity of disease cannot be predicted by its levels.


Prolactin, Stroke

Full Text:



Gawaz M, Langer H, May AE. Platelets in inflammation and atherogenesis. Journal of Clinical Investigation. 2005; 115:3378–84.

Fateh-Moghadam S, Htun P, Tomandl B, Sander D, Stellos K, Geisler T, Langer H, Walton K, Handschu R, Garlichs C, Daniel WG. Hyperresponsiveness of platelets in ischemic stroke. Thrombosis and haemostasis. 2007;97(06):974-8.

Hatano S. Experience from a multicentre stroke register: a preliminary report. Bulletin of the World Health Organization. 1976;54(5):541.

Llibre J, Valhuerdi A, Fernandez O. prevalence of stroke and Associated Risk factors in Older Adults in Havana city and Matanzas Provinus, Cuba (10/66 Population-Based study) MEDICC Review. 2010;12:20–24.

BERN HA. The comparative endocrinology of prolactin. Recent Prog Horm Res. 1968;24:681-720.

Majumdar A. Mangal NS. Hyperprolactinemia. J Hum Reprod Sci. 2013 Jul-Sep; 6(3): 168–175.

Tohgi H, Suzuki H, Tamura K, Kimura B. Platelet volume, aggregation, and adenosine triphosphate release in cerebral thrombosis. Stroke. 1991 Jan;22(1):17-21.

Nieswandt B. Ruggeri ZM. Platelets In Atherothrombosis. Nature medicine. 2002 Nov;8(11):1227-34.

Ben-Jonathan N, Hugo ER, Brandebourg TD, LaPensee CR. Focus on prolactin as a metabolic hormone. Trends in Endocrinology & Metabolism. 2006 Apr 1;17(3):110-6.

Wallaschofski H, Kobsar A, Sokolova O, Eigenthaler M, Lohmann T. Co-activation of platelets by prolactin or leptin-pathophysiological findings and clinical implications. Hormone and metabolic research. 2004 Jan;36(01):1-6.

Tam AA. Kaya C. Baser H. Ersoy R. Cakr B. Mean platelet volume in patients with prolactinoma. Arch. Endocrinol. Metab. 2016;60(4).

Ghelichkhani P, Esmaeili M, Hosseini M, Seylani K. Glasgow Coma Scale and FOUR Score in Predicting the Mortality of Trauma Patients; a Diagnostic Accuracy Study. Emergency. 2018;6(1).

Tripathi SK, Kamble P and Muddeshwar MG. Serum Prolactin Level in Patients of Ischemic stroke. International Journal of Contemporary Medical Research. 2016. 3(12).


  • There are currently no refbacks.