Dr . V. R. Aditya Chainulu, Dr. V. Padma, Dr. Indhuja


Sepsis is an extreme and dysregulated inflammatory response to infection that is distant from the primary site of infection resulting in end-organ damage. Appearance of acute kidney injury (AKI) during sepsis raises patient morbidity, predicts higher death rates, has a significant effect on functions of multiple organs, is associated with a prolonged duration of stay in the intensive care unit, and hence warrants appropriate healthcare resources. Pathophysiology, diagnostic procedures and appropriate therapeutic interventions in sepsis are still highly debatable despite impressive advances in several medical fields. The overwhelmingly high mortality rate of sepsis is not reduced despite multiple immunomodulatory agents showing promise in preclinical studies. Major obstacles to progress in understanding, early diagnosis, and implementing effective therapeutic modalities in sepsis-induced AKI comprise minimal histopathological data, few animal models closely emulating human sepsis, and a relative lack of specialized diagnostic tools. Here we analyse 100 ICU patients who developed AKI and sepsis as a major etiological factor as well as mortality indicator.


Sepsis, Acute Kidney Injury, Mortality, Intensive Care Unit, etiology.

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