OVEREXPRESSION of HER2/neu GENE: CORRELATION WITH HISTOLOGICAL GRADING IN BREAST CARCINOMA

Dr. Renu Sahay, Dr. Vikas Goyal, Dr. Shailza

Abstract


Background: Carcinoma of the breast is the most common non- skin malignancy in women. Prognosis
and management of breast cancer are inuenced by variables such as stage, grade, hormone receptor
status of oestrogen(ER), progesterone(PR) and Human epidermal growth factor receptor2 (HER2/neu) overexpression. Aim to
correlate grade of tumour with HER2/neu receptor status of breast carcinoma.
Methods: The present study has been conducted in Pathology department, MLB Medical College, Jhansi. The tissue material
has been obtained from patients admitted in surgery department for breast conservation surgery or modied radical
mastectomy and tissue blocks present in pathology department has been utilized. All samples were subjected for routine
histological examination and immunohistochemical analysis.
Results: The patients were >20 years of age; 56% of tumours were right sided; 51% tumours were histopathologically grade 2
and 98% were invasive breast carcinoma. By immunohistochemistry, out of 45 cases, 19 was HER2/neu positive; Out of which
the 6 cases (31.57%) with the score of 2+ (grade II), 9 cases (47.37%) with score 3+ (grade III) and 4 cases (21.06%) score of 0/1+
(negative) (grade I).
Conclusions: Assessment of hormone receptors for clinical management of breast cancer patients is strongly advocated to
provide prognostic information and best therapeutic options. A signicant correlation was observed between HER2/neu
immunoreactivity and the histological grade of tumour.


Keywords


Breast cancer, histological grade, HER2/neu overexpression, immunohistochemistry (IHC).

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References


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