Dr. S. Aruna, M.d., Dr. J. Sowndharya, M.d., Dr. R. S. Monish Anand, M.b.b.s.


AIM: The Aim of the study is to determine the prevalence of Microalbuminuria in newly diagnosed
patients with Type 2 Diabetes Mellitus and to compare the effectiveness of Microalbuminuria with the
fasting Lipid prole in detecting Cardiovascular risk in these patients in terms of Atherogenic Index. Material &Methods: The
study group includes 100 patients with Type 2 Diabetes Mellitus. Patients with urinary tract infection, Macro albuminuria, Renal
failure and Heart failure are excluded from the study. Fasting and post-prandial blood sugar, Fasting Lipid prole, Atherogenic
Index, Creatinine and Urine Albumin are measured in all the patients. The patients were divided in to two groups: Group A
without Microalbuminuria and Group B with Microalbuminuria.
RESULTS: BMI, FBS, PPBS, Total Cholesterol, TGL, Atherogenic Index, Creatinine and Urine Albumin are found to be higher in
Group B compared to Group A patients and Serum HDL is found to be lower in Group B compared to Group A patients. Pearson
correlation coefcient of Atherogenic Indices with Urine Albumin excretion of Group B patients shows that there is a signicant
positive correlation (r = 0.5981).
CONCLUSION: Microalbuminuria can be used as an independent marker for early prediction of Cardiovascular complications
and can be used as a screening procedure in all patients diagnosed with type 2 Diabetes mellitus.


Microalbuminuria, Atherogenic Index, Cardiovascular Diseases, Diabetesmellitus.

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Dr. Kedam. Durga Prasad, Dr. Perumalla Rajaseker (2012) Study Of Microalbuminuria As A Cardiovascular Risk Factor In Type 2 Diabetes Mellitus, Asian J Pharm Clin Res, 2012, Vol 5, Issue 2, 42-43.

Coen D.A. Stehouwer, Yvo M. Smulders, 2006, Microalbuminuria And Risk For Cardiovascular Disease: Analysis Of Potential Mechanisms,2006, J Am Socnephrol 17: 2106-2111.

Matthew R. Weir, 2007, Microalbuminuria And Cardiovascular Disease, 2007, Clin J Am Socnephrol 2: 581-590.

Dick De Zeeuw, Hans-Henrikparving, And Robert H. Henning, 2006, Microalbuminuria As An Early Marker For Cardiovascular Disease, 2006, J Am Socnephrol 17: 2100–2105.

James T. Lane, 2004, Microalbuminuria As A Marker Of Cardiovascular And Renal Risk In Type 2 Diabetes Mellitus: A Temporal Perspective, 2004, Am J Physiol Renal Physiol 286: F442–F450.

Hisashi Adachi, 2014, Microalbuminuria Is An Independent Prognostic Information For Cardiovascular Disease, 2014, Atherosclerosis 237, 106 – 107.

Jan Skov Jensen, Bo Feldt-Rasmussen, Svendstrandgaard, Marianne Schroll, Knut Borch-Johnsen, Arterial Hypertension, Microalbuminuria, And Risk Of Ischemic Heart Disease, Hypertension. 2000;35:898-903.

Vito M. Campesea, Stefano Bianchib And Roberto Bigazzib, Is Microalbuminuria A Predictor Of Cardiovascular And Renal Disease In Patients With Essential Hypertension?,Current Opinion In Nephrology And Hypertension 2000, 9:143-147.

Roberto Pedrinellia, Giulia Dell’omoa, Giuseppe Pennob And Mario Mariania, Non-Diabetic Microalbuminuria, Endothelial Dysfunction And Cardiovascular Disease, Vascular Medicine 2001; 6: 257–26.

R Habbal, Ar Sekhri, M Volpe, Prevalence Of Microalbuminuria In Hypertensive Patients And Its Associated Cardiovascular Risk In Clinical Cardiology: Moroccan Results Of The Global I-Search Survey – A Sub-Analysis Of A Survey With 21 050 Patients In 26 Countries Worldwide, Cardiovasc J Afr 2010; 21: 200–205.

Seema Basi, Md, Msci, Piere Fesler, Md, Albert Mimran, Md, Julia B. Lewis, Md, Microalbuminuria In Type 2 Diabetes And Hypertension Amarker,Treatmenttarget,Orinnocentbystander?Diabetes Care, Volume 31, Supplement 2, February 2008, S194-S201.

P H Winocour, Microalbuminuria - Worth Screeningfor In Early Morning Urine Samples In Diabetic, Hypertensive, And Elderlypatients, Bmj Volume 304, 9 May 1992, 1196-1197.

Aida Jimenez Corona,David Rivera Martinez,Mauricio Hernandez Avila, Steven Haffner,Ken Williams,Ma.Elena Gonz´Alez Villalpando,Jesus Simon, Michael Stern, And Clicerio Gonzalez-Villalpando, Microalbuminuria As A Predictor Of Myocardial Infarction In A Mexican Population: The Mexico City Diabetes Study, Kidney International, Vol. 68, Supplement 97 (2005), Pp. S34–S39.

Chien-Yu Lin, Ming-Fong Chen, Lian-Yu Lin, Chiau-Suongliau, Yuan-Teh Lee And Ta-Chen Su, Insulin Resistance Is The Major Determinant For Microalbuminuria In Severe Hypertriglyceridemia: Implication For High-Risk Stratification, Inter Med (2008)47: 1091-1097.

Roberto Bigazzi, Stefano Bianchi, Ducciobaldari, Gianpaolosgherri, Giorgio Baldari, Vito M. Campese, Microalbuminuria In Salt-Sensitive Patients A Marker For Renal And Cardiovascular Risk Factors, Hypertension Vol 23, No 2 February 1994, 195-199.

A Varghese, R Deepa, M Rema, V Mohan, Prevalence Of Microalbuminuria In Type 2 Diabetes Mellitus At A Diabetes Centre In Southern India, Postgrad Med J 2001;77:399–402.

Coen D.A. Stehouwer, Mari-Anne Gall, Jos W.R. Twisk, Elisabeth Knudsen, Jef J. Emeis, And Hans-Henrikparving, Increased Urinary Albumin Excretion, Endothelial Dysfunction, And Chronic Low-Grade Inflammation In Type 2 Diabetes- Progressive,Interrelated,Andindependentlyassociated Withriskofdeath, Diabetes 51:1157–1165, 2002.

Knut Borch-Johnsen, Bo Feldt-Rasmussen, Svendstrandgaard, Marianne Schroll, Jan Skov Jensen, Urinary Albumin Excretion An Independent Predictor Of Ischemic Heart Disease, Arteriosclerthrombvasc Biol. 1999;19:1992-1997.

Ulrichtebbe, Peter Bramlage, Martinthoenes,D,W. Dieter Paar, Nicolas Danchin, Massimovolpe, Jochen Schrader, Georg Noll, Michael Burnier, Michael Böhm, Prevalenceofmicroalbuminuriaanditsassociatedcardiovascularrisk:Germanandswissresultsoftherecentglobali-Search Survey, Swiss Med Wkly2009;139(33–34):473–480.

Andreas Festa,Ralph D’agostino, Jr., George Howard,Leena Mykka ¨ Nen, Russell P. Tracy, And Steven M. Haffner,Inflammation And Microalbuminuria In Nondiabetic And Type 2 Diabetic Subjects: The Insulin Resistance Atherosclerosis Study,Kidney International, Vol. 58 (2000), Pp. 1703–1710.

Hiroki Yokoyama,Tomomi Aoki,Masumi Imahori, And Masae Kuramitsu,Subclinical Atherosclerosis Is Increased In Type 2 Diabetic Patients With Microalbuminuria Evaluated By Intima-Media Thickness And Pulse Wave Velocity, Kidney International, Vol. 66 (2004), Pp. 448–454.

Christos Kalofoutis Bsc, Christina Piperi Phd, Anastasioskalofoutis Md, Fred Harris Phd, David Phoenix Phd, Jaipaul Singh Phd, Type Ii Diabetes Mellitus And Cardiovascular Risk Factors: Current Therapeutic Approaches, Expclincardiol 2007;12(1):17-28.

G.Dogra, L.Rich, K.Stanton, G.F.Watts, Endothelium-Dependent And Independent Vasodilation Studied At Normoglycemia In Type I Diabetes Mellitus With And Without Microalbuminuria, Diabetologia (2001)


Hans L. Hillege, Md; Vaclav Fidler, Phd; Gilles F.H. Diercks, Md; Wiek H. Van Gilst, Phd; Dick De Zeeuw, Md; Dirk J. Van Veldhuisen, Md; Rijk O.B. Gans, Md; Wilbert M.T. Janssen, Md; Diederick E. Grobbee, Md; Paul E. De Jong, Md, Urinary Albumin Excretion Predicts Cardiovascular And Noncardiovascular Mortality In General Population, Circulation- 2002;106:1777-1782.

Janakakaralliedde And Giancarlo Viberti, Microalbuminuria And Cardiovascular Risk, American Journal Of Hypertension, 2004, 17: 986-993.

C. Lydakis And G.Y.H. Lip, Microalbuminuria And Cardiovascular Risk, Q J Med 1998; 91:381–391.

Js Jensen, B Feldt-Rasmussen, K Borch-Johnsen, P Clausen, M Appleyard And G Jensen, Microalbuminuria And Its Relation To Cardiovascular Disease And Risk Factors. A Population-Based Study Of 1254 Hypertensive Individual, Journal Of Human Hypertension (1997) 11, 727–732.

Roberto Pedrinelli, Vitantonio Di Bello, Giosu6 Catapano, Luigi Talarico, Franco Materazzi, Gino Santoro, Costantinogiusti, Franco Mosca, Eliomelillo, And Mauro Ferrari, Microalbuminuria Is A Marker Of Left Ventricular Hypertrophy But Not Hyperinsulinemia In Nondiabetic Atherosclerotic Patient, Arteriosclerosis And Thrombosis 1993;13:900-906.

M. Murussi, N. Campagnolo, M. O. Beck, J. L. Gross And S. P. Silveiro, Micro- And Macroalbuminuria And Mortality M. Murussi Et Al., High-Normal Levels Of Albuminuria Predict The Development Of Micro- And Macroalbuminuria And Increased Mortality In Brazilian Type 2 Diabetic Patients: An 8-Year Follow-Up Study, Diabet. Med. 2007, 24, 1136–1142.

Pallavi S. Kanthe , Bheemshetty S. Patil , Shrilaxmibagali , Anita Deshpande , Gouharbanushaikh , Manjunathaaithala, Atherogenic Index As A Predictor Of Cardiovascular Risk Among Women With Different Grades Of Obesity, International Journal Of Collaborative Research On Internal Medicine & Public Health, 2012, Vol. 4 No. 10, 1767-1774.

Miladadobiášová, Jiri Frohlich, Michaela Šedová, Marian C. Cheung, And B. Greg Brown, Cholesterol Esterification And Atherogenic Index Of Plasma Correlate With Lipoprotein Size And findings On Coronary Angiography, J. Lipid Res. 2011. 52: 566–571.

Muhammad Saiedullah, Mdmahfuzurrahmanand Mohammad Abdul Haisiddique, Atherogenic Index And Female Gender Are Independent Determents Of Chronic Subclinical Inflammation In Subjects With Type 2 Diabetes Mellitus, Diabetes Case Rep, Volume 1, Issue 3, 2016, 1-4.

Vandanasaini, Kamna Singh, Meghakataria, Amitayadav And Ritu Singh, Atherogenic Index Of Plasma And Oxidised Ldl In Overt Hypothyroidism In North Indian Female Population, Biochem Anal Biochem 2: 141, Issue 4, 2013, 1-3.

Akifacay, Memnunesenaulu, Ahmetahsen, Gulayozkececi, Kasimdemir, Ufukozuguz, Serefyuksel, Gurselacarturk, Atherogenic Index As A Predictor Of Atherosclerosis In Subjects With Familial Mediterranean Fever, Medicina 50 (2014) 329-333.

S. Bhardwaj, J. Bhattacharjee1, M.K Bhatnagar, S. Tyagi, Atherogenic Index Of Plasma, Castelli Risk Index And Atherogenic Coefficient- New Parameters In Assessing Cardiovascular Risk, Ijpbs |Volume 3| Issue 3 |Jul-Sep|2013|359-364.

Subinaydatta, Mrinal Pal, Comparison Between Different Methods Of Urine Collection For Estimation Of Albumin-Creatinine Ratio In Patients With Type-2 Diabetes Mellitus, Advances In Biological Chemistry, 2013, 3, 403-407.


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